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Introduction PLATELETS IN HEMOSTASIS AND THROMBOSIS＆Chairman，WALTER H．SEEGERS 1

1．The Blood Platelets—Past，Present and Future＆Leandro M．Tocantins 3

2．Platelets in the Peripheral Circulation＆Herbert J．Berman and George P．Fulton 7

Ⅰ．PLATELETS IN BLOOD VESSEL INTEGRITY 21

3．Morphology and Dynamics of Endothelium＆Rudolf Altschul 23

4．Capillary Resistance and Its Relation to Bleeding＆Jeno Kramar 41

5．Studies on Hemostasis in Vivo＆Walter O．Cruz 49

GE ERAL DISCUSSION，＆Wissler，Fulton，Tocantins，Cruz，Ungar，Sharnoff，Thomas，Kramár 61

Ⅱ．PLATELET CLUMPING＆Chairman，C．LOCKARD CONLEY 65

6．Platelet(Viscous)Metamorphosis＆Alan A．Sharp 67

7．Morphological Studies on the Mechanism of Viscous Metamorphosis of Platelets＆Robert L．Rosenthal and Soonu B．Vyas 89

8．Phase Microscopy and the Enumeration of Blood Platelets＆Robert Feissly 99

9．Natural Thrombocyte Agglutinating Systems：Thrombocyte Agglutinating Factors(TAg and TAg＇)in Plasma＆R．G．Mason，E．Carwile LeRoy and Kenneth M Brinkhous 111

10．In Vitro Platelet Aggregation in Relation to Met？s，Macromolecules and Surfaces＆Charles E．Brambel 123

Ⅲ．PHYSIOLOGY AND PATHOLOGY OF HEMOSTASIS＆Chairman，C．LOCKARD CONLEY 133

11．Multiple Factors in Hemorrhage＆Louis B．Jaques 135

DESIGNATED DISCUSSION，＆Marjorie B．Zucker 141

GENERAL DISCUSSION，＆Roskam，Chandler，Bergsagel，Cruz，Rosenthal，Sharp，Conley， Brinkhous，Gollub，Jaques，Harrington，Brambel，Surgenor 145

Ⅳ．ROLE OF PLATELETS IN THROMBOSIS＆Chairman，ROBERT W．WISSLER 151

12．Role of Platelets in the Formation of a Hemostatic Plug＆Jacques Roskam 153

13．Dietary Lipids and the Clotting Mechanism with Particular Reference to Lysis＆Wilbur A．Thomas 163

14．The Influence of Induced Atherosclerosis on Calcium，Phosphorus and Sulfate in the Arterial Wall＆Albert J．Boyle，D．S．McCann，D．T．Forman and H．Kagen 173

15．Lipids，Platelets and Atherosclerosis＆James F．Mustard，H．G．Downie，E．A．Murphy and H．C．Rowsell 191

DESIGNATED DISCUSSION，＆Robert W．Wissler 205

GENERAL DISCUSSION，＆Pirkle，McDonald，Merskey，Thomas，Deutsch，Mandel，Spaet，Mustard，Cruz 209

Ⅴ．PLATELETS IN THE PHYSIOLOGY OF HEMOSTASIS，WITH PARTICULAR REFERENCE TO BLEEDING TIME＆Chairman，RAYMOND W．MONTO 217

DESIGNATED DISCUSSION，＆Monto，Spaet，Roskam，Fulton，Cruz，Jaques，Sharp，Lüscher 219

GENERAL DISCUSSION，＆Quick，Sharp，Maupin，Weiner，Spaet，Roskam，Fulton，Cruz，Jaques，Snart，Kupfer，Jacobson，Friedman，Sharnoff，Monto 230

Ⅵ．PHYSIOLOGICAL AND BIOCHEMICAL MECHANISMS OF PLATELETS IN BLOOD COAGULATION＆Chairman，ARMAND J．QUICK 239

6．Platelet Fractions and Prothrombin Activation＆Walter H．Seegers 241

7．The Synthesis of Glycerolphosphatides＆Erich Baer 253

18．The Platelet Lipids：Their Identification，Quantification and Behavior in Clotting Systems in Vitro＆Stanley B．Troup，Claude F．Reed，Guido V．Marinetti and Scott N．Swisher 265

19．The Thromboplastic Activity of Some Soybean Phospholipids＆William J．Williams 277

20．Biophysical Aspects of Platelet Reaction Mechanisms in Clotting＆Douglas M．Surgenor and Donald F．Hoelzl Wallach 289

21．The Lipids of Human Erythrocytes and Platelets and Their Effects on Thromboplastin Formation＆Percy Barkhan，Melvin J．Silver and Louise M．O＇Keefe 303

GENERAL DISCUSSION，＆Gross，Wissler，Surgenor，Born，Vroman，Caen，O＇Brien，Marcus，Davis 319

Ⅶ．PLATELET FRACTIONS＆Chairman，SHIRLEY A．JOHNSON 327

22．The Antifibrinolytic Activity of Platelets＆Norma Alkjaersig 329

23．Studies on Platelet Factor 4＆Erwin Deutsch and Walter Kain 337

24．The Nature of the Lipoprotein of Human Platelets and Erythrocytes＆George Y．Shinowara 347

GENERAL DISCUSSION，＆Quick，Beller，O＇Brien，Shanberge，Dreskin，Jürgens，Henstell，Alkjaersig，Deutsch，Shinowara 357

Ⅷ．METABOLISM OF PLATELETS＆Chairman，KENNETH M．BRINKHOUS 363

25．The Breakdown of Phospholipids and of Other Phosphorus Compounds During Coagulation of Platelet-rich Plasma＆Gustav V．R．Born and M．Peter Esnouf 365

26．Changes in Platelet Adenosine Triphosphate Concentration and Phosphate Distribution During Viscous Metamorphosis and Clot Retraction＆Marjorie B．Zucker and Jennie Borrelli 383

27．Studies on the Uptake of Serotonin by Platelets＆Herbert Weissbach and Betty G．Redfield 393

28．Metabolic Aspects of Normal and Pathological Platelets＆Rudolf Gross 407

29．Effects of Sulfhydryl Inhibitors on Structural Stability of Platelets＆J．Leo Koppel 423

GENERAL DISCUSSION，＆Hartert，Lasch，Shinowara，Ungar，Born，Zucker，Harrington 430

Ⅸ．CLOT RETRACTION OF PLATELETS＆Chairman，KENNETH M．BRINKHOUS 435

30．Platelets in Clot Retraction＆C．Lockard Conley 437

31．Retraction Activity of the Platelets： Biochemical Background and Physiological Significance＆Ernst F．Lüscher 445

32．Time Lapse Photography of Clot Retraction＆Giorgio Ballerini and Walter H．Seegers 455

GENERAL DISCUSSION，＆Baldini，Cruz，Hartert，Zucker，Lüscher，Beller，Weissbach，Seegers 456

Ⅹ．BANQUET SPEECH＆Chairman，ROBERT C．HORN，JR 461

33．The Mystery of Indo-European Expansion＆Clark Hopkins 463

Ⅺ．THROMBOCYTOPENIC BLEEDING＆Chairman，MAXWELL M．WINTROBE 473

34．Evaluation of the Degree of Bleeding in Thrombocytopenic States＆Dudley P．Jackson 475

35．Thrombocytopenic Bleeding and Preservation of Platelets＆Phin Cohen and Frank H．Gardner 485

36．Platelets and Heparin＆Robert C Hartmann 499

GENERAL DISCUSSION，＆Baldini，Weiss，Weiner，Lasch，Ebaugh，Caen，Gross，Maupin，Dentsch，Lüscher，Tullis，Jackson，Gardner，Hartmann，Johnson 512

Ⅻ．ALTERED PLATELET FUNCTION＆Chairman，LEANDRO M．TOCANTINS 523

37．Specific Platelet Alterations Related to Hematological Disorders＆Shirley A．Johnson，Raymond W．Monto and John W．Rebuck 523

38．Volumetric and Ultrastructural Studies of Abnormal Platelets＆John W．Rebuck，Jeanne M．Riddle，Morden G．Brown，Shirley A．Johnson and Raymond W．Monto 533

39．The Qualitative Platelet Diseases＆Orhan N．Ulutin 553

40．Some Qualitative and Quantitative Aspects of Platelet Function in Normal，Thrombocytopenic，and Thrombocytopathic States＆Helen Czemobilsky and Benjamin Alexander 565

GENERAL DISCUSSION，＆Tocantins，Schmidt，Braunsteiner，Marcus，Zucker，Henstell，Wall，Merskey，Deutsch，Spaet，Johnson，Rebuck，Ulutin 585

ⅩⅢ．HEMATOPOIETIC ASPECTS AND PHYSICAL PROPERTIES OF PLATELETS＆Chairman，JOHN W．REBUCK 593

41．Studies on the Origin，Production and Destruction of Platelets＆Eugene P．Cronkite，Victor P．Bond，Theodor M．Fliedner，Donald A．Paglia and Emil R．Adamik 595

42．Biodynamics of Thrombopoiesis＆Riojun Kinosita and Susumn Ohno 611

43．Electron Microscopy of Blood Platelets＆Herbert Braunsteiner 617

44．Thrombokinetics＆Clement A．Finch 629

GENERAL DISCUSSION，＆Rebuck，Schulman， Sharnoff，Baldini，Cooney，Wood，Schroeder，Gardner，Cronkite，Finch，Kinosita 634

ⅩⅣ．LABELING，LIFE SPAN AND PRESERVATION＆Chairman，CARL V．MOORE 641

45．Platelet Labeling with Radioisotopes and in Vivo Platelet Survival＆T．T．Odell，Jr 643

46．Survival of Platelets Transfused into Thrombocytopenic Recipients＆Julius R．Krevans 651

ⅩⅤ．IMMUNOLOGICAL ASPECTS OF PLATELETS＆Chairman，CARL V．MOORE 657

47．Immune Reactions of Platelets＆William J．Harrington and Grace Arimura 659

48．Mechanisms of Immunogenic Platelet Damage＆Peter A．Miescber and Fred Gorstein 671

49．The Identification and Isolation of Antiplatelet Proteins＆James L．Tullis 679

50．Use of the Fluorescent Antibody Technique in the Detection of Platelet Antibodies＆Charles C．Sprague 689

GENERAL DISCUSSION，＆Pisciotta，Baldini，Odell 696

51．Closing Remarks＆Carl V．Moore 699

Index 701