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Part 1．GENES AND CHROMOSOMES 1

Chapter 1．Genes Are DNA 2

Chapter 2．Genes Code for Proteins 26

Edited by Esther Siegfried,Pennsylvania State University,AltoonaChapter 3．Methods in Molecular Biology and Genetic Engineering 42

Edited by John Brunstein,University of British ColumbiaChapter 4．The Interrupted Gene 79

Edited by Donald Forsdyke,Queens UniversityChapter 5．The Content of the Genome 98

Chapter 6．Genome Sequences and Gene Numbers 118

Chapter 7．Clusters and Repeats 139

Chapter 8．Genome Evolution 159

Chapter 9．Chromosomes 189

Edited by Hank W.Bass,Florida State UniversityChapter 10．Chromatin 220

Part 2．DNA REPLICATION AND RECOMBINATION 262

Chapter 11．The Replicon 263

Edited by Stephen D.Bell,Oxford UniversityChapter 12．Extrachromosomal Replicons 282

Edited by S？ren Johannes S？rensen ＆ Lars Hestbjerg Hansen,University of CopenhagenChapter 13．Bacterial Replication Is Connected to the Cell Cycle 299

Edited by Barbara Funnell,University of TorontoChapter 14．DNA Replication 320

Edited by Peter Burgers,Washington University Medical SchoolChapter 15．Homologous and Site-Specific Recombination 348

Edited by Hannah L.Klein ＆ Samantha Hoot,New York University Langone Medical CenterChapter 16．Repair Systems 391

Chapter 17．Transposable Elements and Retroviruses 419

Edited by Damon Lisch,University of California,BerkeleyChapter 18．Somatic Recombination and Hypermutation in the Immune System 458

Edited by Paolo Casali,Institute for Immunology,University of California,IrvinePart 3．TRANSCRIPTION AND POSTTRANSCRIPTIONAL MECHANISMS 503

Chapter 19．Prokaryotic Transcription 504

Edited by Richard Gourse,University of Wisconsin,MadisonChapter 20．Eukaryotic Transcription 546

Chapter 21．RNA Splicing and Processing 573

Edited by Xiang-Dong Fu,University of California,San Diego,School of MedicineChapter 22．mRNA Stability and Localization 618

Edited by Ellen Baker,University of Nevada,RenoChapter 23．Catalytic RNA 642

Edited by Douglas J.Briant,University of VictoriaChapter 24．Translation 665

Edited by Cheryl Keller Capone,Pennsylvania State UniversityChapter 25．Using the Genetic Code 704

Edited by John Perona,University of California,Santa BarbaraPart 4．GENE REGULATION 734

Chapter 26．The Operon 735

Edited by Liskin Swint-Kruse,University of Kansas School of MedicineChapter 27．Phage Strategies 767

Chapter 28．Eukaryotic Transcription Regulation 795

Chapter 29．Epigenetic Effects Are Inherited 828

Edited by Trygve Tollefsbol,University of Alabama,BirminghamChapter 30．Regulatory RNA 861

Glossary 881

Index 905