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Session 1 Innovative Methodology of Peptide/Protein Synthesis 1

N-to-C Sequential Ligation Method for Protein Total Synthesis&Renliang Yang,Wen Hou,Xiaohong Zhang,Chuan-Fa Liu 3

Total Solid-phase Combinatorial Synthesis of Biologically Active N-Decanoyl Depsipeptide Derivatives from Natural Products&Chuanguang Qin,Qiuyu Wang,Lin Li,Tingting Wei,Jin Ren 6

The Synthesis of Alkyne-human Relaxin-2 for Labeling with Different Azido Molecules by Click Chemistry&Feng Lin,Linda Chan,Laszlo Otvos Jr.and John D.Wade 12

4-Methoxybenzyloxymethyl Group as a Thiol Protecting Group for Cysteine to Prevent Racemization in Fmoc Chemistry&Hajime Hibino,Yuji Nishiuchi 15

Bio-Inspired Thrombomodulin Conjugate Engineering via Recombinant and Bio-Orthogonal Conjugation Technique&Hailong Zhang,Jacob Weingart,Rui Jian gand Xue-Long Sun 18

Acid-catalyzed N-S Acyl Shift for Preparing Peptide Thioesters Using Fmoc Chemistry&Yibo Qiu,Clarence T.T.Wong and James P.Tam 22

Solid-Phase Synthesis of Side-Chain-Protected Peptides via a Linker-Modified Resin&Zhi-Ping Huang,Ming Zhang 25

Development of Peptide Modification Methods to Widely Expand Peptide Structural Diversity and Its Applications&Xinjun Zhang,Wentao Zhang 28

Session 2 Peptide/Protein Material Sciences 35

Synthetic and Self-assembly Studies of a Series of Gemini Peptides&Changhai Cao,Meiwen Cao,Daohong Xia,Hai Xu 37

Fabrication of Globular Protein/Polysaccharide-PAA Aggregates&Naipu He,Sikai Huang,Xi Du,Weigang Zhao,Shengfang Lu,Xiaoqian Han 44

High-efficiency Cellular Penetrable Superparamagnetic Nanoparticle Complexation with Tat Peptide Conjugates&Chenhong Wang,Lei Qiao,Keliang Liu 47

Biological Activities of Integrin-binding Peptides Derived from Laminins on Alginate and Chitosan Matrices&Kazuhiro Sato,Yuji Yamada,Kentaro Hozumi,and Motoyoshi Nomizu 53

Session 3 Technological Advances in Peptide Purification and Analysis 57

Intein-mediated Expression of Cyclic Sunflower Trypsin Inhibitor in E.coli&Shunyi He,Ting Chen,Wei Zhang,Rong Feng,Youshang Zhang 59

Perfection of the Universal Method for Screening Affinity Adsorbents Used for Phosphorylated Peptide Isolation Utilizing Gold Colloids&Qinqin Wei,Wei Wang,Bicui Wang,Jun Wang,Zhi Yuan 63

Session 4 Peptide drug discovery and design 67

New Paradigms for Drug Discovery and Development:Design of Multivalent Ligands for the Treatment of Disease&VictorJ.Hruby,Takashi Yamamoto,Padma Nair,Minying Cai,Josef Vagner,Jatinder Josan,Robert J.Gillies,LipingXu,David Morse,Peg Davis,Shou-Wu Ma,Tally Largent-Milnes,Josephine Lai,Eva Varga,Todd Vanderah,Frank Porreca 69

Edible Biologics:Orally Active Peptide Bradykinin B1 Receptor Antagonists for Inflammatory Pain Treatment&James P.Tam,Clarence T.T.Wong 72

Small-sized BACEI Inhibitors:In-silico Design and Synthesis&Yoshio Hamada,Harichandra D.Tagad,Yoshiaki Kiso 77

Design of Novel Relaxin-3 Agonist Analogues as Potential Neurological Regulators&Fazel Shabanpoor,M.Akhter Hossain,Feng Lin,Ross A.D.Bathgate,Andrew Gundlach,John D.Wade 80

2-Oxoamides Based on Amino Acids and Dipeptides as Selective Phospholipase A2 Inhibitors Presenting Anti-inflammatory Activity&George Kokotos 83

N-Methylation of Cyclized Melanotropine Peptides:A New Perspective of Drug Discovery for Melanocortin System&Minying Cai,Jennifer Bao,Morgan R.Zingsheim,Johannes G Beck,Florian Opperer,Lucas Doedens,Horst Kessler Victor J.Hruby 86

Design,Synthesis,and Pharmacological Evaluation of Novel Tasiamide B Derivatives:Selective Inhibitors of BACEl&Jian Liu,Siming Yang,Wei Zhang,Ning Ding,Yingxia Li 89

Autophagy Inhibition Promotes HDACI-induced Apoptosis in MCF-7 Breast Cancer Cells&Shimiao Wang,Xiaohui Li,Zhilong Xiu 92

The Mechanism of Amyloid Protein Aggregation and the Design of Fibrillization Inhibitors&Meng-Rong Ma and Yan-MeiLi 97

Anti-HIV-l Small Molecule-Peptide Conjugates for Studying Target Binding of Small Molecule Fusion Inhibitors&Chao Wang,Weiguo Shi,Lifeng Cai,Kun Wang,Keliang Liu 101

A Peptide-based Fluorescence Probe for Trypsin Activity and a Potent Inhibitor&Junchen Wu,Tian He,Carsten Schmuck 104

Development of RGD-MEK1/2 Inhibitor Conjugates for Targeted Delivery in Melanoma Treatment&Xiaoxiao Li,Cao Wang,Shanyun Gao,Jianjun Hou,Zhangjun Yang,Lihe Zhang,Zili Chen,Yun Wu 107

Chemical Synthesis of Irisin and Detection in Human Blood&Aydar Sabirov,Xiang-Qun Chen,Rong-Ming Lyu,Qing Tian,Siok L.Dun Nae J.Dun,and Jaw-Kang Chang 111

Bifunctional Peptides with a μ／δ Opioid Activity Profile as Analgesic Drug Candidates with Reduced Side Effects&Jinguo Ding,Thi M.-D.Nguyen,Carole Lemieux,Nga N.Chung,and Peter W.Schiller 113

Discovery and Mechanism ofa New Antitumor Peptide&Liangyou Wang,Dongdong Lu 116

Session 5 Peptide Mimetics and Conjugates 119

Exploring the Function and Transport Mechanism of Lipidated Proteins Using Synthetic Proteins&Si-Yu Zhang,Yong-Xiang Chen 121

Session 6 Bioactive Peptides 127

Cationic Antifungal Lipopeptides:Conjugation of a Fatty Acid Compensates for Shortening the Peptidic Chain&Dorit Avrahami and Yechiel Shai 129

Cyclic ω-conotoxin MVIIA,Antimicrobial Activity Generated by Cyclization&Xinya Hemu and James P.Tam 146

STY39,a Novel Alpha-Melanocyte-stimulating Hormone Analogue,Reduces Acute Lung Injury in Rats with Hemorrhagic Shock and Endotoxin Challenge&Zhigang Wang,Yeping Tian 149

Author Index 153

Subject Index 155