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INDEX 1

VOLUME 1 1

INDEX 1

1.BIOLOGY OF THE NORMAL JOINT 1

Section Ⅰ BIOLOGY OF THE NORMAL JOINT 1

2.COLLAGEN AND ELASTIN 27

3.MATRIX GLYCOPROTEINS,PROTEOGLYCANS,AND CARTILAGE 41

4.PROTEINASES AND MATRIX DEGRADATION 55

5.BIOMECHANICS OF JOINTS 73

6.MACROPHAGES,DENDRITIC CELLS,AND FOLLICULAR DENDRITIC CELLS 79

Section Ⅱ IMMUNE AND INFLAMMATORY RESPONSES 79

7.GENETICS OF RHEUMATIC DISEASES 95

8.T LYMPHOCYTES 113

9.B CELLS 131

10.RHEUMATOID FACTOR 151

11.ANTINUCLEAR ANTIBODIES 161

12.IMMUNE COMPLEXES 175

13.COMPLEMENT 185

14.NEUTROPHILS AND EOSINOPHILS 195

15.PROSTAGLANDINS,LEUKOTRIENES,AND RELATED COMPOUNDS 211

16.THE MAST CELL 225

17.ENDOTHELIAL CELLS AND NITRIC OXIDE 239

18.PLATELETS 255

19.FIBROBLAST FUNCTION AND FIBROSIS 263

20.CYTOKINES 275

21.APOPTOSIS 291

22.AUTOIMMUNITY 305

Section Ⅲ EVALUATION OF THE PATIENT 321

23.EPIDEMIOLOGY OF THE RHEUMATIC DISEASES 321

24.EVIDENCE-BASED RHEUMATOLOGY 335

25.EXAMINATION OF THE JOINTS 347

26.MONARTICULAR ARTHRITIS 367

27.POLYARTICULAR ARTHRITIS 379

28.WEAKNESS 387

29.THE EYE AND RHEUMATIC DISEASE 393

30.THE SKIN 401

Section Ⅳ MUSCULOSKELETAL PAIN AND EVALUATION 417

31.FIBROMYALGIA 417

32.OCCUPATIONAL AND RECREATIONAL MUSCULOSKELETAL DISORDERS 429

33.SPORTS MEDICINE 439

34.NECK PAIN 457

35.SHOULDER PAIN 475

36.LOW BACK PAIN 509

37.HIP AND KNEE PAIN 525

38.ANKLE AND FOOT PAIN 547

39.TEMPOROMANDIBULAR JOINT PAIN 557

40.HAND AND WRIST PAIN 569

Section Ⅴ DIAGNOSTIC TESTS AND PROCEDURES 583

41.ASPIRATION AND INJECTION OF JOINTS AND SOFT TISSUES 583

42.SYNOVIAL FLUID ANALYSIS AND SYNOVIAL BIOPSY 605

43.IMAGING 621

44.ARTHROSCOPY AND SYNOVECTOMY 685

45.LABORATORY EVALUATION OF INFLAMMATION 697

46.BIOLOGIC MARKERS 705

Section Ⅵ SPECIAL ISSUES 713

47.UNTRITION AND RHEUMATIC DISEASES 713

48.PSYCHOSOCIAL MANAGEMENT OF RHEUMATIC DISEASES 729

49.GERIATRICS AND THE RHEUMATIC DISEASES 735

50.ALTERNATIVE CARE FOR ARTHRITIS AND RELATED MUSCULOSKELETAL DISEASES 739

51.CHRONIC PAIN MANAGEMENT 753

52.REHABILITATION OF PATIENTS WITH RHEUMATIC DISEASES 763

53.HEALTH OUTCOME ASSESSMENT 777

Section Ⅶ CLINICAL PHARMACOLOGY 789

54.DEVELOPING A CLINICAL TRIAL DESIGN 789

55.NONSTEROIDAL ANTHNFLAMMATORY DRUGS 799

56.GLUCOCORTICOIDS 823

57.METHOTREXATE 841

58.SULFASALAZINE 853

59.ANTIMALARIAL DRUGS 859

60.GOLD AND PENICILLAMINE 869

61.IMMUNOREGULATORY DRUGS 879

62.BIOLOGIC AGENTS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS 899

63.TETRACYCLINES 913

64.ETIOLOGY AND PATHOGENESIS OF RHEUMATOID ARTHRITIS 921

Section Ⅷ RHEUMATOID ARTHRITIS 921

VOLUME 2 921

65.CLINICAL FEATURES OF RHEUMATOID ARTHRITIS 967

66.TREATMENT OF RHEUMATOID ARTHRITIS 1001

67.FELTY S SYNDROME 1023

68.APPROACHES TO THE TREATMENT OF SJOGREN S SYNDROME 1027

Section Ⅸ SPONDYLOARTHROPATHIES 1039

69.ANKYLOSING SPONDYLITIS 1039

70.REITER S SYNDROME AND UNDIFFERENTIATED SPONDYLOARTHROPATHY 1055

71.PSORIATIC ARTHRITIS 1071

72.ENTEROPATHIC ARTHRITIS 1081

Section Ⅹ SYSTEMIC LUPUS ERYTHEMATOSUS AND RELATED SYNDROMES 1089

73.PATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS 1089

74.CLINICAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS 1105

75.MANAGEMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS 1125

76.ANTIPHOSPHOLIPID ANTIBODY SYNDROME 1145

Section Ⅺ VASCULITIC SYNDROMES 1153

77.CLASSIFICATION OF VASCULITIS 1153

78.GLANT CELL ARTERITIS AND POLYMYALGIA RHEUMATICA 1155

79.VASCULITIS ASSOCIATED WITH ANTINEUTROPHIL CYTOPLASMIC ANTIBODY 1165

80.POLYARTERITIS AND RELATED DISORDERS 1185

81.HYPERSENSITIVITY VASCULITIS(SMALLVESSEL CUTANEOUS VASCULITIS) 1197

82.BEHCET S DISEASE 1205

Section Ⅻ SCLERODERMA AND MIXED CONNECTIVE TISSUE DISEASES 1211

83.SCLERODERMA 1211

84.MIXED CONNECTIVE TISSUE DISEASE AND OTHER OVERLAP SYNDROMES 1241

Section XIII STRUCTURE,FUNCTION,AND DISEASE OF MUSCLE 1261

85.SKELETAL MUSCLE 1261

86.INFLAMMATORY DISEASES OF MUSCLE AND OTHER MYOPATHIES 1273

Section XIV RHEUMATIC DISEASES OF CHILDHOOD 1297

87.JUVENILE RHEUMATOID ARTHRITIS 1297

88.SYSTEMIC LUPUS ERYTHEMATOSUS,JUVENILE DERMATOMYOSITIS,SCLERODERMA,AND VASCULITIS 1315

Section XV CRYSTAL-ASSOCIATED SYNOVITIS 1339

89.GOUT AND HYPERURICEMIA 1339

90.DISEASES ASSOCIATED WITH DEPOSITION OF CALCIUM PYROPHOSPHATE OR HYOROXYAPATITE 1377

Setion XVI OSTEOARTHRITIS,POLYCHONDRITIS,AND HERITABLE DISORDERS 1391

91.PATHOGENESIS OF OSTEOARTHRITIS 1391

92.CLINICAL FEATURES OF OSTEOARTHRITIS 1409

93.MANAGEMENT OF OSTEOARTHRITIS 1419

94.HERITABLE DISORDERS OF STRUCTURAL PROTEINS 1433

95.RELAPSING POLYCHONDRITIS 1463

Section XVII ARTHRITIS RELATED TO INFECTION 1469

96.BACTERIAL ARTHRITIS 1469

97.LYME DISEASE 1485

98.MYCOBACTERIAL AND FUNGAL INFECTIONS 1493

99.RHEUMATIC MANIFESTATIONS OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION 1507

100.VIRAL ARTHRITIS 1519

101.ACUTE RHEUMATIC FEVER 1529

Section XVIII ARTHRITIS ACCOMPANYING SYSTEMIC DISORDERS 1541

102.AMYLOIDOSIS 1541

103.SARCOIDOSIS 1551

104.IRON STORAGE DISEASE 1559

105.HEMOPHILIC ARTHROPATHY 1567

106.HEMOGLOBINOPATHIES AND ARTHRITIS 1575

107.ARTHRITIS ACCOMPANYING ENDOCRINE AND METABOLIC DISORDERS 1581

108.HYPERTROPHIC OSTEOARTHROPATHY 1589

109.MUSCULOSKELETAL SYNDROMES IN MALIGNANCY 1595

Section XIX DISORDERS OF BONE AND STRUCTURAL PROTEIN 1611

110.BIOLOGY,PHYSIOLOGY,AND MORPHOLOGY OF BONE 1611

111.METABOLIC BONE DISEASE 1635

112.OSTEONECROSIS 1653

Section XX TUMORS INVOLVING JOINTS 1667

113.TUMOR AND TUMOR-LIKE LESIONS OF JOINTS AND RELATED STRUCTURES 1667

Section XXI RECONSTRUCTIVE SURGERY FOR RHEUMATIC DISEASE 1691

114.INTRODUCTION TO SURGICAL MANAGEMENT OF PATIENTS WITH ARTHRITIS 1691

115.PRINCIPLES OF RECONSTRUCTIVE SURGERY 1699

The Hand and Wrist 1699

The Elbow 1718

The Shoulder 1728

The Cervical Spine 1736

The Hip 1743

The Knee 1759

The Ankle and Foot 1769

The Surgical Management of Juvenile RheVmatoid Arthritis 1781