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Ⅰ.BASIC PRINCIPLES 1

1．Introduction Bertram G.Katzung,MD,PhD 1

2．Drug Receptors Pharmacodynamics Henry R.Bourne,MD, Mark von Zastrow,MD,PhD 9

3．Pharmacokinetics Pharmacodynamics:Rational Dosing the Time Course of Drug Action Nicholas H.G.Holford,MB,ChB,FRACP 35

4．Drug Biotransformation Maria Almira Correia,PhD 51

5．Basic Clinlcal Evaluation of New Drugs Barry A.Berkowitz,PhD, Bertram G.Katzung,MD,PhD 64

Ⅱ.AUTONOMIC DRUGS 75

6．Introduction to Autonomic Pharmacology Bertram G.Katzung,MD,PhD 75

7．Cholinoceptor-Activating Cholinesterase-Inhibiting Drugs Achilles J.Pappano,PhD, 92

8．Cholinoceptor-Blocking Drugs Achilles J.Pappano,PhD, Bertram G.Katzung,MD,PhD 107

9．Adrenoceptor-Activating Other Sympathomimetlc Drugs Brian B.Hoffman,MD 120

10．Adrenoceptor Antagonist Drugs Brian B.Hoffman,MD 138

Ⅲ.CARDIOVASCULAR-RENAL DRUGS 155

11．Antihypertenslve Agents Neal L.Benowitz,MD 155

12．Vasodilators the Treatment of Angina Pectorls Bertram G.Katzung,MD,PhD, Kanu Chatterjee,MB,FRCP 181

13．Cardiac Glycosides Other Drugs Used in Congestive Heart Failure Bertram G.Katzung,MD,PhD, William W.Parmley,MD 200

14．Agents Used in Cardiac Arrhythmias Luc M.Hondeghem,MD,PhD, Dan M.Roden,MD 219

15．Diuretic Agents Harlan E.Ives,MD,PhD 245

16．Histamine,Serotonin, the Ergot Alkaloids Bertram G.Katzung,MD,PhD, David J.Julius,PhD 265

Ⅳ.DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE 265

17．Vasoactive Peptides Ian A.Reid PhD 292

18．The Eicosanoids:Prostaglandins,Thromboxanes,Leukotrienes, Related Compounds Marie L.Foegh,MD,DSc, Peter W.Ramwell,PhD 311

19．Nitric Oxide,Donors, Inhibitors George Thomas,PhD, Peter W.Ramwell,PhD 326

20．Drugs Used in Asthma Homer A.Boushey,MD 333

Ⅴ.DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM 351

21．Introduction to the Pharmacology of CNS Drugs Roger A.Nicoll,MD 351

22．Sedative-Hypnotic Drugs Anthony J.Trevor,PhD, Walter L.Way,MD 364

23．The Alcohols Susan B.Masters,PhD 382

24．Antiselzure Drugs Roger J.Porter,MD, Brian S.Meldrum,MB,PhD 395

25．General Anesthetics Anthony J.Trevor,PhD, Ronald D.Miller,MD 419

26．Local Anesthetics Ronald D.Miller,MD, Bertram G.Katzung,MD,PhD 436

27．Skeietal Muscle Relaxants Ronald D.Miller,MD, Bertram G.Katzung,MD,PhD 446

28．Pharmacologic Management of Parkinsonism Other Movement Disorders Michael J.Aminoff,MD,FRCP 463

29．Antipsychotic Agents Lithium William Z.Potter,MD,PhD, Leo E.Hollister,MD 478

30．Antidepressant Agents William Z.Potter,MD,PhD, Leo E.Hollister,MD 498

31．Opioid Analgesics Antagonists Walter L.Way,MD,Howard L.Fields,MD,PhD, Mark A.Schumacher,PhD,MD 512

32．Drugs of Abuse Thomas R.Kosten,MD,and Leo E.Hollister,MD 532

Ⅵ.DRUGS USED TO TREAT DISEASES OF THE BLOOD,INFLAMMATION, GOUT 549

33．Agents Used in Anemias;Hematopoietic Growth Factors Daniel V.Santi,MD,PhD, Susan B.Masters,PhD 549

34．Drugs Used in Disorders of Coagulation Julie Hambleton,MD, Robert A.O Reilly,MD 564

35．Agents Used in Hyperlipidemia Mary J.Malloy,MD, John P.Kane,MD,PhD 581

36．Nonsteroidal Anti-Inflammatory Drugs,Disease-Modifying Antirheumatic Drugs,Nonopioid Analgesics, Drugs Used in Gout Daniel E.Furst,MD, Tino Munster,MD 596

Ⅶ.ENDOCRINE DRUGS 625

37．Hypothalamic Pituitary Hormones Paul A.Fitzgerald,MD 625

38．Thyroid Antithyroid Drugs Francls S.Greenspan,MD, Betty J.Dong,PharmD 644

39．Adrenocorticosteroids Adrenocortical Antagonists George P.Chrousos,MD, Andrew N.Margioris,MD 660

40．The Gonadal Hormones Inhibitors George P.Chrousos,MD,Emmanouil N.Zoumakis,PhD, Achille Gravanis,PhD 679

41．Pancreatic Hormones Antidlabetic Drugs Martha S.Nolte,MD, John H.Karam,MD 711

42．Agents That Affect Bone Mineral Homeostasls Daniel D.Bikle,MD,PhD 735

43．Beta-Lactam Antibiotics Other Inhibitors of Cell Wall Synthesis Henry F.Chambers,MD 754

Ⅷ.CHEMOTHERAPEUTIC DRUGS 754

44．Chloramphenicol,Tetracyclines,Macrolldes,Clindamycin, Streptogramins Henry F.Chambers,MD 774

45．Aminoglycosides Spectinomycin Henry F.Chambers,MD 784

46．Sulfonamides,Trimethoprim, Quinolones Henry F.Chambers,MD 793

47．Antimycobacterial Drugs Henry F.Chambers,MD 803

48．Antifungal Agents Don Sheppard,MD, Harry W.Lampiris,MD 814

49．Antiviral Agents Sharon Safrin,MD 823

50．Miscellaneous Antimicrobil Agents;Disinfectants,Antiseptics, Steriiants Henry F.Chambers,MD 845

51．Clinical Use of Antimicrobial Agents Harry W.Lampiris,MD, Daniel S.Maddix,PharmD 854

52．Basic Principies of Antiparasitic Chemotherapy Ching Chung Wang,PhD 869

53．Antiprotozoal Drugs Philip J.Rosenthal,MD, Robert S,Goldsmith,MD,DTM H 882

54．Clinical Pharmacology of the Anthelmintic Drugs Robert S.Goldsmith,MD,DTM H 903

55．Cancer Chemotherapy Sydney E.Salmon,MD, Alan C.Sartorelli,PhD 923

56．Immunopharmacology Douglas F.Lake,PhD,Emmanuel T.Akporiaye,PhD, Evan M.Hersh,MD 959

Ⅸ.TOXICOLOGY 987

57．Introduction to Toxicology:Occupational Environmental Gabriel L.Plaa,PhD 987

58．Heavy Metal Intoxication Chelators Michael J.Kosnett,MD,MPH 999

59．Management of the Poisoned Patlent Kent R.Olson,MD 1011

60．Special Aspects of Perinatal Pediatric Pharmacology Gideon Koren,MD 1025

Ⅹ.SPECIAL TOPICS 1025

61．Special Aspects of Geriatric Pharmacology Bertram G.Katzung,MD,PhD 1036

62．Dermatologic Pharmacology Dirk B.Robertson,MD, Howard I.Maibach,MD 1045

63．Drugs Used in Gastrointestinal Diseases David F.Altman,MD 1064

64．Therapeutic Toxic Potential of Over-the-Counter Agents Robin L.Corelli,PharmD, Mary Anne Koda-Kimble,PharmD 1077

65．Botanicals( Herbal Medications ) Nutritional Supplements Cathi E.Dennehy,PharmD, Candy Tsourounis,PharmD 1088

66．Rational Prescribing Prescription Wrlting Paul W.Lofholm,PharmD, Bertram G.Katzung,MD,PhD 1104

AppendixⅠ. Vaccines,Immune Globulins, Other Compiex Biologic Products Harry W.Lampiris,MD, Daniel S.Maddix,PharmD 1113

AppendixⅡ. Important Drug Interactions Their Mechanisms Phillp D.Hansten,PharmD 1122

Index 1135