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第一部分 奋斗历程 1

医学高峰的眺望者——记国际著名肾脏病学专家、中国工程院院士刘志红 3

第二部分 学术贡献 21

一、刘志红院士的学术成就与学术思想 23

二、刘志红院士的主要学术论文 34

（一）肾脏病学的发展 34

Nephrology in China 35

中国肾脏病诊治三十年回顾与展望 40

系统生物学——推动肾脏病临床研究的新动力 46

转化医学：医学模式的转化，医学发展的方向 49

（二）IgA肾病 51

Epidemiologic Data of Renal Diseases from a Single Unit in China：Analysis Based on 13 519 Renal Biopsies 52

Interleukin-1Receptor Antagonist Allele：Is It a Genetic Link between Henoch-Schonlein Nephritis and IgA Nephropathy？ 58

Long-term Renal Survival and Related Risk Factors in Patients with IgA Nephro- pathy：Results from a Cohort of 1155 Cases in a Chinese Adult Population 63

A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients 72

Corticosteroid Therapy in IgA Nephropathy with Minimal Change-like Lesions： a Single-centre Cohort Study 80

MiR-223 Downregulation Promotes Glomerular Endothelial Cell Activation by Upregulating Importin α4 and α5 in IgA Nephropathy 86

Long-Term Outcome of IgA Nephropathy Patients with Recurrent Macroscopic Hematuria 99

（三）狼疮性肾炎 106

Multitarget Therapy for Induction Treatment of Lupus Nephritis A Randomized， Controlled Trial 107

Sex Differences in Estrogen Receptor Gene Polymorphism and Its Association with Lupus Nephritis in Chinese 118

Epistatic Effect of Plasminogen Activator Inhibitor 1and β3-Fibrinogen Genes on Risk of Glomerular Microthrombosis in Lupus Nephritis 124

Association of Interleukin-10 Gene-592 A/C Polymorphism with the Clinical and Pathological Diversity of Lupus Nephritis 133

Evaluation of Renal Vascular Lesions Using Circulating Endothelial Cells in Patients with Lupus Nephritis 139

Circulating Thrombomodulin and Vascular Cell Adhesion Molecule-1and Renal Vascular Lesion in Patients with Lupus Nephritis 146

Peritubular Capillary C4d deposition in Lupus Nephritis Different from Antibody-mediated Renal Rejection 152

Effects of Mycophenolic Acid on Endothelial Cells 157

（四）糖尿病肾病 165

Glucose Transporter （GLUT1）Allele （Xba Ⅰ-）Associated with Nephropathy in Non-insulin-dependent Diabetes Mellitus 166

Amylin Deposition in the Kidney of Patients with Diabetic Nephropathy 171

Rhein Protects Pancreatic β-Cells from Dynamin-Related Protein-1-Mediated Mitochondrial Fission and Cell Apoptosis Under Hyperglycemia 178

Evaluation of Podocyte Lesion in Patients with Diabetic Nephropathy：Wilms’ Tumor-1Protein Used as a Podocyte Marker 189

Rhein Improves Renal Lesion and Ameliorates Dyslipidemia in db/db Mice with Diabetic Nephropathy 196

Combined Therapy of Rhein and Benazepril on the Treatment of Diabetic Nephro- pathy in db/db Mice 203

Treatment of Diabetic Nephropathy with Tripterygium Wilfordii Hook F Extract： a Prospective，Randomized，Controlled Clinical Trial 209

Treatment of db/db Diabetic Mice with Triptolide：a Novel Therapy for Diabetic Nephropathy 218

Renal Histologic Changes and the Outcome in Patients with Diabetic Nephropathy 228

（五）肥胖相关性肾病 238

Obesity-Related Glomerulopathy：Insights from Gene Expression Profiles of the Glomeruli Derived from Renal Biopsy Samples 239

Podocyte Lesions in Patients with Obesity-Related Glomerulopathy 247

Obesity-Related Glomerulopathy in China：a Case Series of 90 Patients 253

Roles of Mast Cells and Monocyte Chemoattractant Protein-1 in the Renal Injury of Obesity-related Glomerulopathy 260

Obesity-Related Glomerulopathy：Body Mass Index and Proteinuria 266

（六）足细胞及足细胞病 276

Downregulation of MicroRNA-30 Facilitates Podocyte Injury and Is Prevented by Glucocorticoids 277

Anti-Phospholipase A2 Receptor Antibody in Membranous Nephropathy 284

Triptolide Protects Podocytes from Puromycin Aminonucleoside Induced Injury in vivo and in vitro 291

Triptolide Reduces Proteinuria in Experimental Membranous Nephropathy and Protects Against C5b-9-induced Podocyte Injury in vitro 300

Etiology and Clinical Characteristics of Membranous Nephropathy in Chinese Patients 309

Long-term Outcome and Prognostic Factors of Idiopathic Membranous Nephro- pathy in the Chinese Population 317

Mercury-Induced Membranous Nephropathy： Clinical and Pathological Features 326

Thromboembolic Complications in Membranous Nephropathy Patients with Nephrotic Syndrome-a Prospective Study 332

The Clinical Course and Long -Term Outcome of Primary Focal Segmental Glomerulosclerosis in Chinese Adults 338

Evaluation of MicroRNAs miR-196a，miR-30a-5P，and miR-490 as Biomarkers of Disease Activity among Patients with FSGS 346

Relationship between Serum Soluble Urokinase Plasminogen Activator Receptor Level and Steroid Responsiveness in FSGS 354

Plasma Micro RNA-186 and Proteinuria in Focal Segmental Glomerulosclerosis 363

（七）遗传性肾病 375

Spectrum of Clinical Features and Type Ⅳ Collagen α-Chain Distribution in Chinese Patients with Alport Syndrome 376

Quantitative Analysis of Type Ⅳ Collagen Subchains in the Glomerular Basement Membrane of Patients with Alport Syndrome with Confocal Microscopy 386

A Complete Genomic Analysis of the Apolipoprotein E Gene in Chinese Patients with Lipoprotein Glomerulopathy 397

Fabry Disease：Renal Biopsy-Proven Cases from China 402

（八）血液净化和肾移植 410

Influence of CYP3A5 and MDR1Polymorphisms on Tacrolimus Concentration in the Early Stage after Renal Transplantation 411

Endothelial Dysfunction in Patients with Severe Acute Pancreatitis：Improved by Continuous Blood Purification Therapy 416

Recipient-Derived Cells in the Tissue Repair of Renal Allografts 423

Improvement of Monocyte Function and Immune Homeostasis by High Volume Continuous Venovenous Hemofiltration in Patients with Severe Acute Pancreatitis 427

三、刘志红院士的主要学术著作 434

中国肾脏病学（上、下册） 434

肾脏病临床集锦——精选病例100例 436

Podocytopathy 439

慢性肾脏病矿物质与骨异常诊治指导 442

肾脏病科普丛书（一套四册） 444

四、刘志红院士的重要学术报告 447

脂蛋白肾病：新的疾病，新的启迪 448

马兜铃酸肾病：一个虽被认识 但未解决的问题 451

积极应对继发性肾脏病带来的挑战 455

局灶节段性肾小球硬化的诊断：摆脱组织形态学束缚的努力 457

足细胞病的治疗：免疫抑制剂，还是足细胞保护 460

重视系统性淀粉样变性的诊断和治疗 463

急性肾损伤：提高认识，加强防治 466

重视慢性肾脏病-矿物质和骨异常的诊断和治疗 469

五、刘志红院士学术年表 472

刘志红院士论文目录 472

刘志红院士主编的重要学术著作 534

刘志红院士医疗、教学、科研成果目录 535

刘志红院士获奖目录 537

第三部分 治学之道 539

学问为天下之公器 541

打造一流临床中心 推进医学科技创新——在国家临床医学研究中心启动会上的讲话 543

梅花香自苦寒来——刘志红院士科研团队推进我国首个肾脏病国家重点基础科研计划项目纪实 545

架起展翅飞翔的双翼——刘志红院士创建国际标准化肾脏疾病生物样本库、开展队列研究纪实 550

直挂云帆济沧海 553

心系苍生谋福祉——刘志红院士领导编撰《CKD-MBD诊治指导》纪实 556

天道酬勤有志人 558

临床医学科学家的诠释者 560

唯有精神才能够认识精神 565

求善、求真、求实 567

传道、授业、解惑 569

第四部分 大师风范 571

在南京大学医学院2012级新生开学典礼暨医学生白大衣授予及宣誓仪式上的讲话 573

自省 专注 悲悯 仁爱——《我的名字叫医生》《我的名字叫护士》征文集序言 575

科学求索、民族精神、社会责任 577

一位临床医学科学家的战略视野——记刘志红院士的育才之道 581

走向世界医学之巅的那抹红 584

大医之道——护理人员心目中的刘志红院士 587

创新意识，严谨作风，刻苦精神 596

一片冰心在玉壶 598

谁言寸草心，报得三春晖 602

医学苦海中的一座灯塔 604

第五部分 社会影响 607

一个女人、母亲、学者和学科带头人——记我印象中的刘志红院士 609

刘志红院士与中华肾脏病学会 613

加强国际交流合作 展现中国学者风采 616

第六部分 人生风采 619

医疗科研 621

学术交流 624

教书育人 629

重要时刻 631

珍贵合影 634

工作之余 635